What the Research Says About SoftWave and Stem Cells
Laboratory and animal studies have found that shockwaves can stimulate stem and progenitor cells, the body's own repair cells. SoftWave's FDA clearance (510(k) K210451) covers a temporary increase in local blood circulation, relief of minor aches and pains, and activation of connective tissue.
- Circulation (2006): In rats, low-energy shockwaves increased the recruitment of endothelial progenitor cells (a type of stem cell) to the treated muscle. Aicher A, et al. “Low-energy shock wave for enhancing recruitment of endothelial progenitor cells.” Circulation, 2006.
- Cytotherapy (2014): In the lab, shockwaves maintained and increased stem-cell markers in human and rat fat-derived stem cells. Schuh CM, et al. “In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells.” Cytotherapy, 2014.
- Stem Cell Research & Therapy (2018): In the lab, radial shockwaves increased the growth and self-renewal of human mesenchymal stem cells. Zhang H, et al. “Radial shockwave treatment promotes human mesenchymal stem cell self-renewal and enhances cartilage healing.” Stem Cell Research & Therapy, 2018.
These studies were done in lab dishes and in animals. They show a biological mechanism; they are not proof of what will happen in any one patient, and individual results vary. FDA clearance record: 510(k) K210451.



